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Interleukin-6 (IL-6) and interleukin-11 (IL-11) are known to influence osteoclast formation and bone resorption. In order to determine whether IL-6 and IL-11 could independently support human osteoclast formation, these factors were added to cultures of human peripheral blood mononuclear cells of the monocyte (CD14(+)) fraction in the presence of macrophage colony-stimulating factor (M-CSF). Under these conditions, IL-6 and IL-11 induced the formation of multinucleated cells which were positive for TRAP, VNR, and calcitonin receptor and capable of lacunar resorption. Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. These results indicate that IL-6 and IL-11, which are thought to play a role in several osteolytic bone disorders, are directly capable of inducing osteoclast formation by a RANKL-independent mechanism.

Type

Journal article

Journal

Bone

Publication Date

01/2003

Volume

32

Pages

1 - 7

Keywords

Acid Phosphatase, Adult, Carrier Proteins, Cells, Cultured, Female, Humans, Interleukin-11, Interleukin-6, Isoenzymes, Male, Membrane Glycoproteins, Middle Aged, Osteoclasts, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Recombinant Proteins, Tartrate-Resistant Acid Phosphatase