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Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.

Original publication

DOI

10.1161/01.RES.0000070112.80711.3D

Type

Journal article

Journal

Circ Res

Publication Date

02/05/2003

Volume

92

Pages

827 - 839

Keywords

Chromosome Mapping, Enzyme Precursors, Humans, Matrix Metalloproteinases, Models, Molecular, Multigene Family, Protein Conformation, Tissue Inhibitor of Metalloproteinases