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Fluoride assays for oxygenases: The 2-oxoglutarate-dependent oxygenase BBOX catalyses the final step in carnitine biosynthesis and is a medicinal chemistry target. We report that BBOX can hydroxylate fluorinated substrates analogues with subsequent release of a fluoride ion, thereby enabling an efficient fluorescence-based assay.

Original publication

DOI

10.1002/cbic.201200256

Type

Journal article

Journal

Chembiochem

Publication Date

23/07/2012

Volume

13

Pages

1559 - 1563

Keywords

Biocatalysis, Fluorescence, Fluorides, Humans, Hydrocarbons, Fluorinated, Magnetic Resonance Spectroscopy, Molecular Structure, Protons, gamma-Butyrobetaine Dioxygenase