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Synthetic glucocorticoids (GCs) are frequently used to treat painful and inflamed tissues and joints. However GCs also cause unwanted side effects, inhibiting cell proliferation as well as normal cell activity. Whether these effects are transient or long-term is unknown. Inhibition of cell proliferation can lead to either quiescence or senescence. Whereas quiescence is reversible, senescence is irreversible in vivo and hence leads to a permanent loss of normal cell functionality.

Original publication

DOI

10.1016/j.joca.2013.02.141

Type

Journal article

Journal

Osteoarthritis and Cartilage

Publisher

Elsevier

Publication Date

01/04/2013

Volume

21

Pages

63 - 64