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The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.

Original publication

DOI

10.1080/17453674.2016.1244750

Type

Journal article

Journal

Acta orthopaedica

Publication Date

12/2016

Volume

87

Pages

15 - 25

Addresses

a Spinal Studies and ISTM , Keele University, and Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust , Oswestry , UK.

Keywords

Musculoskeletal System, Cartilage, Articular, Bone and Bones, Chondrocytes, Humans, Cell Aging, Aging, Intervertebral Disc