We aim to help develop the findings across the full programme of work in the Centre with the goal of identifying new tests or treatments for osteoarthritis, maximising clinical benefit.
We provide staff, including a research nurse and tissue coordinator, and infrastructure to support the following, working closely with the NIHR Clinical Research Network Thames Valley and South Midlands, Oxford Musculoskeletal Biobank, and the departments of Rheumatology, Sports & Exercise Medicine, and Orthopaedics at the Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust:
- Laboratory studies using donated human joint tissues, for example following joint replacement surgery
- Clinical studies which follow groups of individuals with osteoarthritis, or those at risk of the condition
- Clinical trials of new medical or surgical treatments in those with osteoarthritis, or those at risk of the condition
- Collaboration with pharmaceutical and biotechnology industries to maximise the translation of findings from the Centre
Examples of clinical studies include following groups of those with acute knee injury, who have an increased risk of osteoarthritis. OxKIC (Oxford Knee Injury Cohort) and KICK (Knee Injury Cohort at the Kennedy) are two such studies being run by investigators at the Centre.
As part of these studies, participants donate blood, urine and synovial fluid samples which are tested by researchers for possible new markers, with the aim of understanding if we can predict who develops osteoarthritis, and why.
PROMOTE (a randomised controlled trial of methotrexate for painful knee OA – a drug used successfully to treat other forms of arthritis, to study if this improves pain in knee OA). We are proud to be one of 13 centres across the UK participating in this national trial supported by Arthritis Research UK.