Anastasios Chanalaris

• CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.

  Miotla Zarebska J. et al, (2017), Osteoarthritis Cartilage, 25, 406 - 412

• ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’

  Yang CY. et al, (2017), Osteoarthritis Cartilage

• TNFAIP6 AND SAA1 MRNA LEVELS ARE ELEVATED IN PERIPHERAL BLOOD CELLS FOLLOWING DESTABILISING KNEE INJURIES

  Chanalaris A. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S82 - S83

• THE REGULATION OF PATHOLOGICAL SIGNALLING BY THE CHONDROCYTE CILIUM

  McFie M. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S177 - S178

• DIFFERENTIAL REGULATION OF FIBROBLAST GROWTH FACTOR-3 CONTROLS FGFR1:FGFR3 BALANCE IN CHONDROCYTES AFTER CARTILAGE INJURY

  Khan SN. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S137 - S137

• DIFFERENTIAL INFLAMMATORY GENE EXPRESSION PATTERNS IN JNK2 KNOCKOUT MICE IN RESPONSE TO IL1, CARTILAGE INJURY AND SURGICALLY INDUCED OSTEOARTHRITIS

  Ismail HM. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S146 - S146

• Nociceptive sensitizers are regulated in damaged joint tissues, including the articular cartilage, when osteoarthritic mice display pain behaviour

  Driscoll C. et al, (2015), Arthritis and Rheumatology

• Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis

  Gardiner MD. et al, (2015), Osteoarthritis and Cartilage, 23, 616 - 628

• Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

  Gardiner MD. et al, (2015), Osteoarthritis Cartilage, 23, 616 - 628

• THE TISSUE SPECIFIC ROLE OF SIRT1 IN JOINT INFLAMMATION AND ANABOLIC CARTILAGE GENE EXPRESSION

  Sacitharan PK. et al, (2015), OSTEOARTHRITIS AND CARTILAGE, 23, A33 - A33

• COMMON GENES BETWEEN HUMAN AND RODENT OSTEOARTHRITIS CARTILAGE STUDIES SHOW LITTLE OVERLAP WITH AN INFLAMMATORY GENE-SET

  Chanalaris A., (2015), OSTEOARTHRITIS AND CARTILAGE, 23, A319 - A319

• Subchondral bone gene expression in early knee destabilisation induced osteoarthritis

  Mantovani V. et al, (2014), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 95, A21 - A22

• Regulation of nerve growth factor in the articular cartilage causes pain in murine OA

  Driscoll C. et al, (2014)

• Fibromodulin and tenascin N are potential biomarkers of post-traumatic OA

  Papadopoulou A. et al, (2014), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 95, A22 - A22

• CTGF is released from the pericellular matrix of articular cartilage upon mechanical injury, and promotes the bioavailability of TGF beta

  Tang X. et al, (2014), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 95, A30 - A31

• IL18 IS SECRETED UPON JOINT INJURY AND IS A KEY PATHOGENIC CYTOKINE IN MURINE OSTEOARTHRITIS

  Vincent TL. et al, (2014), OSTEOARTHRITIS AND CARTILAGE, 22, S131 - S132

• IDENTIFICATION OF A GENE SIGNATURE FOR OSTEOARTHRITIS BY COMPARING MICROARRAY DATA FROM RODENT AND HUMAN CARTILAGE STUDIES

  Chanalaris A., (2014), OSTEOARTHRITIS AND CARTILAGE, 22, S348 - S349

• CTGF IS RELEASED FROM THE PERICELLULAR MATRIX OF ARTICULAR CARTILAGE UPON MECHANICAL INJURY, AND CONTROLS THE BIOAVAILABILITY OF TGF beta

  Tang X. et al, (2014), OSTEOARTHRITIS AND CARTILAGE, 22, S13 - S13

• CARTILAGE INJURY REGULATES NERVE GROWTH FACTOR (NGF) IN VTTRO AND IN VIVO AND DRIVES PAINFUL BEHAVIOUR IN MURINE OA

  Driscoll C. et al, (2014), OSTEOARTHRITIS AND CARTILAGE, 22, S35 - S35

• Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.

  Lo Cascio L. et al, (2014), Genesis, 52, 110 - 119

• Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.

  Chong KW. et al, (2013), Arthritis Rheum, 65, 2346 - 2355

• Mapping pathogenesis of arthritis through small animal models.

  Vincent TL. et al, (2012), Rheumatology (Oxford), 51, 1931 - 1941

• Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

  Burleigh A. et al, (2012), Arthritis Rheum, 64, 2278 - 2288

• Gene expression profiling and proteomic analysis of cartilage degradation in a mouse model of osteoarthritis

  Gardiner MD. et al, (2012), BRITISH JOURNAL OF SURGERY, 99, 38 - 38

• Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loading

  Burleigh A. et al, (2012), ARTHRITIS RESEARCH & THERAPY, 14

• Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation.

  Lomas C. et al, (2011), Eur Cell Mater, 22, 178 - 189

• Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in a case of donor cell-derived acute myeloid leukaemia following allogeneic sex mismatched umbilical cord blood transplantation for chronic myeloid leukaemia.

  Castleton AZ. et al, (2010), Br J Haematol, 151, 285 - 288

• Deletions of Immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia

  Nacheva EP. et al, (2010), BMC Genomics, 11

• Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia.

  Nacheva EP. et al, (2010), BMC Genomics, 11

• 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

  Steele AJ. et al, (2009), Blood, 114, 1217 - 1225

• Copy number variants: Distribution in patients with coronary atherosclerosis

  Gancheva K. et al, (2009), Biotechnology and Biotechnological Equipment, 23, 1095 - 1100

• FISH mapping of Philadelphia negative BCR/ABL1 positive CML.

  Virgili A. et al, (2008), Mol Cytogenet, 1

• Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.

  Lawrence KM. et al, (2005), FASEB J, 19, 831 - 833

• Erratum: Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway (Biochemical and Biophysical Research Communication (2005) 328 (442-448) DOI: 10.1016/j.bbrc.2005.01.001)

  Chanalaris A. et al, (2005), Biochemical and Biophysical Research Communications, 330

• Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway.

  Chanalaris A. et al, (2005), Biochem Biophys Res Commun, 328, 442 - 448

• Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression.

  Lawrence KM. et al, (2003), FASEB J, 17, 2313 - 2315

• Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes.

  Chanalaris A. et al, (2003), J Mol Cell Cardiol, 35, 1295 - 1305

• SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.

  Chanalaris A. et al, (2003), J Mol Cell Cardiol, 35, 257 - 264

• K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect.

  Lawrence KM. et al, (2002), Circulation, 106, 1556 - 1562

Recent Publications

• CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.

  Miotla Zarebska J. et al, (2017), Osteoarthritis Cartilage, 25, 406 - 412
• ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’

  Yang CY. et al, (2017), Osteoarthritis Cartilage
• TNFAIP6 AND SAA1 MRNA LEVELS ARE ELEVATED IN PERIPHERAL BLOOD CELLS FOLLOWING DESTABILISING KNEE INJURIES

  Chanalaris A. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S82 - S83

• THE REGULATION OF PATHOLOGICAL SIGNALLING BY THE CHONDROCYTE CILIUM

  McFie M. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S177 - S178

• DIFFERENTIAL REGULATION OF FIBROBLAST GROWTH FACTOR-3 CONTROLS FGFR1:FGFR3 BALANCE IN CHONDROCYTES AFTER CARTILAGE INJURY

  Khan SN. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S137 - S137