- Murphy Group | Cartilage Biology and Repair Research Group
My project aims to better understand microRNA function in healthy and diseased chondrocytes. Chondrocytes are the exclusive cell type in cartilage - a tissue responsible for the weight bearing and near friction-free movement in the joints. As a consequence it is vital to understand the principles by which chondrocyte are regulated in both healthy and injured and diseased cartilage. To better understand these processes my work focuses on investigating the role of microRNAs since recent studies have shown that specific microRNAs can control matrix turnover in articular cartilage.
The aim of my work, therefore, involves identifying functionally important and active microRNA target sites in human chondrocytes using CRISPR/Cas9 genome editing. Furthermore, by doing so, we hope to gain insights into the regulation of microRNA target selection.