Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.

Type

Journal article

Journal

Cell

Publication Date

14/12/2001

Volume

107

Pages

789 - 800

Keywords

Animals, Cells, Cultured, Down-Regulation, Embryo, Mammalian, Extracellular Matrix, GPI-Linked Proteins, Gene Targeting, Humans, Immunohistochemistry, Matrix Metalloproteinase 14, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Matrix Metalloproteinases, Membrane-Associated, Membrane Glycoproteins, Metalloendopeptidases, Mice, Mice, Nude, Muscle, Smooth, Vascular, Mutation, Neoplasm Transplantation, Neoplasms, Experimental, Neovascularization, Pathologic, Neovascularization, Physiologic, Transfection, Tumor Cells, Cultured